What the 2015 Nobel Prizes mean for traditional Chinese medicine
COMMENTARY by Marta Hanson OCTOBER 6, 2015
Scientist Youyou Tu’s Nobel Prize is a sign that Western science has changed how it perceives alternative systems of medicine — but only slightly.
I’m sure I’m not the only one surprised by the announcement that half of the 2015 Nobel Prize in Physiology or Medicine has gone to a researcher who spent her entire career researching traditional Chinese medicine. Based at the Chinese Academy of Traditional Chinese Medicine in Beijing (now the China Academy of Chinese Medical Sciences) since 1965, scientist Youyou Tu, her colleagues, and home institution may well be just as stunned today as I am.
Being granted the Lasker Award is often a good predictor of Nobel Prize prospects. Tu received one in 2011 for her discovery of Artemisinin as an alternative malaria cure to the standard chloroquine, which was quickly losing ground in the 1960s due to increasingly drug-resistant parasites. Scientific research on the pharmaceutically active properties of traditional Chinese medicinals, however, has never been a predictor for such widespread international recognition.
Traditional medical knowledge anywhere in the world has not even been on the radar for Nobel Prize prospects. Until now, that is. So how should we interpret this arguably seismic shift in international attention on traditional Chinese medicine?
Discoveries to be made in historical record
In the question-and-answer session after the announcement at the Karolinska Institute, which awards the Nobels, one of the panelists emphasized not just the quality of Tu’s scientific research, but also the value of recorded empirical experience in the past.
The antifebrile effect of the Chinese herb Artemisia annua (qinghaosu 青蒿素), or sweet wormwood, was known 1,700 years ago, he noted. Tu was the first to extract the biologically active component of the herb — called Artemisinin — and clarify how it worked. The result was a paradigm shift in the medical field that allowed for Artemisinin to be both clinically studied and produced on a large scale.
Tu has always maintained that she drew her inspiration from the medical text of a fourth-century Chinese physician and alchemist named Ge Hong 葛洪 (circa 283-343).
His Emergency Formulas To Keep at Hand (Zhouhou beijifang 肘後備急方) can best be understood as a practical handbook of drug formulas for emergencies. It was a book light enough to keep “behind the elbow” (zhouhou), namely, in one’s sleeve, where Chinese men sometimes carried their belongings. We can discern from Ge’s astute description of his patients’ symptoms that people then suffered not only from malaria but also from other deadly diseases including smallpox, typhoid and dysentery.
Beyond recording the fever-fighting qualities of Artemisia annua, Physician Ge also wrote about how Ephedra sinica (mahuang 麻黃) effectively treated respiratory problems and how arsenic sulphide (“red Realgar,” xionghuang 雄黃) helped control some dermatological problems.
Traditional ingredients, modern drugs
Just because a compound has natural roots and has long been used in traditional medicine is no reason to take it lightly.
You might remember that in 2004, the FDA actually banned ephedra-containing dietary and performance-enhancing supplements. They’d been the cause not only of serious side effects but also several deaths. The ban remains in effect in the U.S. despite a court challenge from ephedra manufacturers. Related drug ephedrine, however, is used to treat low blood pressure and is a common ingredient in over-the-counter asthma medicines.
As for Realgar, its toxicity was well-known in both ancient Greece and Chinese antiquity. In Chinese medical thought, though, skillfully administered toxins may also be powerful antidotes for other toxins. Realgar thus continues to be used in Chinese medicine as a drug that relieves toxicity and kills parasites. Applied topically, it treats scabies, ringworm and rashes on the skin’s surface; taken internally, it expels intestinal parasites, particularly roundworms.
Although biomedicine does not currently use Realgar or its related mineral arsenicals in treatments, Chinese researchers have been studying their anticancer properties for some time now. In 2011, a Chinese researcher at Johns Hopkins University, Jun Liu (with other colleagues), also discovered that the Chinese medicinal plant Tripterygium wilfordii Hook F (lei gong teng 雷公藤 “Thunder God Vine”) is effective against cancer, arthritis and skin graft rejection.
Tu’s groundbreaking work on artemisinin, in fact, can be seen as the tip of the iceberg of the extensive and global scientific study of pharmacologically active Chinese medicinals, including another successful antimalarial Dichroa febrifuga (changshan 常山) that has roots in the new scientific research on Chinese medicinals in 1940s mainland China.
It was validation of this traditional drug as an antimalarial in the 1940s, in fact, that set the foundation for Chinese leader Mao Tse Tung’s directive two decades later in the late 1960s to find a cure for malaria. Indeed, Tu’s research is best understood within the complex politics and history of top-down support from the Chinese government of Chinese medicine in mainland China during the long durée of the 20th century, and not just in the Maoist period.
Even outside mainland China, though, such research has yielded results. In the 1970s, for example, U.S. and Japanese researchers developed the statin drugs used to lower cholesterol from studying the mold Monascus purpureus that makes red yeast rice, well, “red.”
Empirical evidence of the medical efficacy in the rich Chinese medical archive from centuries earlier similarly influenced the initial direction of this research.
Medically bilingual
So is this Nobel Prize for Tu’s discovery a signal that Western science has changed how it perceives alternative systems of medicine? Perhaps, but only slightly.
One of the Karolinska Institute panelists acknowledged that there are many sources from which scientists draw inspiration to develop drugs. Among them, we should not ignore the long history of experiences from the past. As he clarified, such sources may be inspirational, but the old herbs found there cannot be used just as they are. Don’t underestimate the sophisticated methods Tu used to extract the active Artemisinin compound from Artemesia annua, another one of the panelists concluded.
So the Nobel Prize is not only acknowledging this complete transformation of a Chinese herb through modern biomedical science into something powerfully efficacious, but also the millions of lives saved because of its successful application worldwide, particularly in the developing world.
But there’s something else that marks Tu as extraordinary vis-à-vis both her two fellow Nobel Laureates for medicine, William C Campbell and Satoshi Ōmura, and her more Western medically oriented colleagues in pharmacology. She embodies, in both her history and her research, what I call medical bilingualism — the ability not only to read in two different medical languages but to understand their different histories, conceptual differences, and, most importantly for this unexpected news, potential value for therapeutic interventions in the present.
This medical bilingualism is a quality that current researchers mining the same fine line between the empirical knowledge of traditional medical traditions and the highest level of modern biomedical science would be lucky to share with Nobel Laureate Youyou Tu.
Marta Hanson is an associate professor of history of medicine at John Hopkins University. This article originally appeared on The Conversation.
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comments (Ken):
Its great to see acknowledgment – even begrudgingly – of the value of looking at old Asian medicine herbs and prescriptions and seeing what can be singularly extracted from a chemically-complex herb (Qing hao).
This ‘might’ strengthen the connections between modern medicine and traditional medicine – but its really a purely modern biochemical approach to the deal – and the focus seems to be on finding single-herb miracles for drug companies to exploit:
http://www.bdlive.co.za/life/health/2015/10/15/nobel-prize-a-bitter-pill-for-classical-chinese-way
Youyou Tu’s ability to do pure biochemical research and ally that with an understanding of the conditions and realities of ancient texts – well it’s obviously brilliant! And nice to see the famous Ge Hong mentioned – who may be – given the way Chinese history is written – a compilation of a lot of different people than an actual person. In any event , ‘he’ is known as the most famous writer about the ‘internal elixir’ use of herbology – so many of his remedies were also said to help people fly, walk on water, etc. Very fanciful stuff for many scientists I imagine. The poetical nature would have to be taken to account (or something very different was going on then that we don’t know much about any more).
I like the underlying theme being put out there that Chinese herbal medicine was traditionally being used to treat epidemic diseases – was famous for that. Kind of puts a little muscle in it – its not JUST to keep you healthy when you’re already basically functional – ie the ‘pay the doctor to keep you well’ ideal. Not just for the entitled. And as I really believe those water-based Chinese herbal decoctions are miraculous for colds/flus/viruses and epidemic diseases – I’m feeling partly vindicated already. Bring on the herbal potions at the hospital pharmacies for the common cold – I’m waiting! (but not holding my breath)
I hope for the time when modern ‘science’ can actually catch up with the traditional system, rather than see it as being confused and hodgepodge due to lack of obvious chemical differentiation. Perhaps our relentless progression towards multi-factorial research and computational power will be able to determine how traditional ‘pattern’ diagnosis (not to mention just the doctor-patient relationship) can play a factor in better outcome.
This does seem to provide some real validity (of some aspects) traditional Chinese medicine in the eyes of the Overseers. And the research and is actually helped a lot of people – poor and underprivileged. So I’ll say… good job!